Worldshift mifty5/17/2023 ![]() ![]() GENERALLY AVOID: Grapefruit juice may increase the plasma concentrations of mifepristone. ADJUST DOSING INTERVAL: Food may significantly increase the plasma concentrations of mifepristone. Taking mifepristone with meals has been shown to increase serum levels of mifepristone. Grapefruit inhibits the metabolism of mifepristone through the CYP3A4 pathway causing increased serum levels of mifepristone. Labour should be induced by the usual methods if it has not started within 72 hrs following the first administration of Mifty. Mifty alone leads to expulsion in about 60%. Labour induction for expulsion of a dead fetus (fetal death in utero): 600 mg of Mifty in a single oral daily dose for 2 consecutive days. Preparation for the action of prostaglandin analogues in the termination of pregnancy for medical reasons (to reduce the doses of prostaglandin): 600 mg of Mifty taken in a single oral dose, 36-48 hrs prior to scheduled prostaglandin administration which will be repeated as often as indicated. Softening and dilatation of the cervix uteri prior to surgical pregnancy termination: 200 mg Mifty, followed 36-48 hrs later (but not beyond) by a surgical termination of pregnancy. Doses of 4.5 mg/kg or greater in human beings resulted in a compensatory elevation of adrenocorticotropic hormone (ACTH) and cortisol.Īs a medical alternative to surgical termination of intra-uterine pregnancy in early pregnancy: 600 mg Mifty in a single oral dose followed 36-48 hrs later, by the administration of a prostaglandin analogue Misoprostol 400 mcg orally (up to 49 days) or Gemeprost 1 mg vaginally (up to 63 days). The activity of the glucocorticoid dexamethasone in rats was inhibited following doses of 10 to 25 mg/kg of mifepristone. Mifty also exhibits antiglucocorticoid and weak antiandrogenic activity. During pregnancy, the compound sensitizes the myometrium to the contraction-inducing activity of prostaglandins. Doses of 1 mg/kg or greater of mifepristone have been shown to antagonize the endometrial and myometrial effects of progesterone in women. Mifty is a synthetic steroid with antiprogestational effects indicated for the medical termination of intrauterine pregnancy through 49 days' pregnancy. At higher doses, it blocks the effect of cortisol at the glucocorticoid receptor while increasing circulating cortisol concentrations. ![]() It sensitises the myometrium to the contraction-inducing action of prostaglandin. Mifty is a synthetic steroid which blocks the effects of progesterone by competitively binding to the intracellular progesterone receptor. ![]()
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